| Autor: |
Wen-ya Feng, Mingyan Hei, Shaoying Li, Bing Hu, Ling-yun Guo, Tian-ming Chen, Xin Guo, Hui-li Hu, Gang Liu, Su-ying Qian, Bing Liu, Hu-yong Zheng, Yue Xie, Lin-lin Liu |
| Rok vydání: |
2020 |
| Předmět: |
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| DOI: |
10.21203/rs.2.22233/v1 |
| Popis: |
Background: Data on pyogenic liver abscess (PLA) of children in China have been limited. Method: We retrospectively reviewed PLA cases from January 2017 to June 2019 at Beijing Children’s Hospital. Clinical features and pathogens were analyzed. Results: We diagnosed 15 PLA patients in our center. Median age of onset was 3.2 years and the median diagnostic time was 9 days. Four patients (26.7%) had underlying diseases and seven patients (46.7%) had multiple organ involvement. The sensitivity achieved 100% when ultrasound and contrast-enhanced CT scan were combined use to diagnose PLA. Two patients were defined pathogen through metagenomic next-generation sequencing (mNGS). Finally, eleven patients (73.3%) were cured during follow-up time and four patients (26.7%) dead. Compared to the survival group and the death group, the patients in death group were more likely to have multiple organ involved (100 vs. 27%, P < 0.05) and bilateral lobe occupied ( P < 0.05) . Conclusions: PLA often occurs in patients with underlying disease. Multiple organs involved may lead to poor prognosis. mNGS can be a new method to detect pathogen. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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