Acid‐Base and Organic‐Water Distribution Equilibria for Symmetrically‐Substituted P,P′‐Dialkyl Alkylenebisphosphonic Acids

Autor:	Albert W. Herlinger, P. R. Zalupski, Mark P. Jensen, Renato Chiarizia, M. P. Chiarelli
Rok vydání:	2006
Předmět:	Aqueous solution Trimethylsilyl Chemistry General Chemical Engineering Electrospray ionization Inorganic chemistry Potentiometric titration General Chemistry Mass spectrometry Medicinal chemistry Acid dissociation constant Homologous series chemistry.chemical_compound Methylene
Zdroj:	Solvent Extraction and Ion Exchange. 24:177-195
ISSN:	1532-2262 0736-6299
DOI:	10.1080/07366290500498852
Popis:	P,P′‐dialkyl alkylenebisphosphonic acids are powerful metal extraction reagents. The acid dissociation constants for a homologous series of aqueous‐insoluble P,P′‐di‐3‐(trimethylsilyl)‐propyl and aqueous‐soluble P,P′‐diethyl methylene‐, ethylene‐ and propylene‐ bisphosphonic acids were determined in a 70∶30 w/w methanol‐water solvent by potentiometric titration and 31P NMR spectrometry. The values obtained for the diethyl‐substituted acids were compared with those determined in water and used to assess the effect of the medium on the aqueous acid dissociation constants of the lipophilic series of P,P′‐di‐3‐(trimethylsilyl)propyl alkylenebisphosphonic acids. The dependence of the organic/aqueous distribution equilibrium on the aqueous acid concentration was also investigated using electrospray ionization mass spectrometry. The acid dissociation and organic/aqueous distribution properties of the substituted alkylenebisphosphonic acids are discussed in terms of their influence on metal ion extractio...
Databáze:	OpenAIRE
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