Gas chromatographic separation of diastereoisomeric and enantiomeric forms of some fluorinated amino acids on glass capillary columns
| Autor: | K. Živný, Věra Vlasáková, V. Tolman |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
chemistry.chemical_classification
Chromatography Chemistry Elution medicine.drug_class Organic Chemistry Diastereomer Carboxamide General Medicine Biochemistry Chiral resolution Analytical Chemistry Amino acid chemistry.chemical_compound Amide medicine Organic chemistry Gas chromatography Enantiomer |
| Zdroj: | Journal of Chromatography A. 639:273-279 |
| ISSN: | 0021-9673 |
| DOI: | 10.1016/0021-9673(93)80263-8 |
| Popis: | The monofluorinated analogues of 2-aminocarboxylic acids up to C7 were efficiently separated into the diastereomers on glass capillary columns coated with achiral phases BP-1, BP-10 and OV-330. In addition, some difluoro and trifluoro analogues were also measured. Chiral resolution was achieved on capillary well-coated open tubular fused-silica columns coated with chiral phases XE-60- l -Val- l -(1-phenylethyl)amide, Chirasil- l -Val and Behenoyl- l -Val-tert.-butylamide. The separation factors and the Kovats indices of the fluorinated amino acids were determined and compared. The erythro racemates display a higher degree of resolution than the threo ones. The order of elution was found to be the l - after the d -solute on all l -phases. |
| Databáze: | OpenAIRE |
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