Improved determination of brofaromine by capillary gas chromatography and by utilization of a multi-purpose injector
| Autor: | P.H. Degen, J.W. Lauber, F. Risser |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Chromatography
Organic Chemistry Analytical chemistry Improved method General Medicine Injector Biochemistry Capillary gas chromatography Analytical Chemistry law.invention chemistry.chemical_compound chemistry Capillary column law Brofaromine hydrochloride Brofaromine Gas chromatography Retention time |
| Zdroj: | Journal of Chromatography A. 623:191-195 |
| ISSN: | 0021-9673 |
| DOI: | 10.1016/0021-9673(92)85318-n |
| Popis: | A significantly improved method for the determination of the monoamine oxidase A inhibitor brofaromine hydrochloride and its major metabolite is described. A newly constructed multi-purpose injector for capillary column gas chromatography (cGC) was utilised. The injector can be used either in split/splitless or hot or cold quasi-on-column mode. For this purpose it was used in the hot on-column mode. The injector is equipped with a septurn cooling device, allowing injection temperatures of up to 400°C without septum glueing. The utilization of cGC with the new highly thermally stable injector showed improvements over the standard GC procedure in terms of retention time stability and ease of operation. |
| Databáze: | OpenAIRE |
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