Efficacy of deep sedation for patients with intractable electrical storm refractory to anti-arrhythmic drugs

Autor:	Charles Guenancia, Nicolas Clementy, David Hamon, Jean-Marie Urien, Josselin Duchateau, Nicolas Barbarot, C. De Chillou, Laure Champ-Rigot, Jean-Marc Sellal, Vincent Galand, R Martins, Eloi Marijon, Rodrigue Garcia, Estelle Gandjbakhch, F. Sacher
Rok vydání:	2020
Předmět:	business.industry Sedation medicine.medical_treatment Hospital mortality Sedation procedure Refractory Anesthesia Extracorporeal membrane oxygenation Medicine Anti arrhythmic medicine.symptom Cardiology and Cardiovascular Medicine business Anti-Arrhythmia Agents
Zdroj:	European Heart Journal. 41
ISSN:	1522-9645 0195-668X
Popis:	Background Sympathetic overactivity is implicated in the initiation and maintenance of electrical storm (ES). Deep sedation has empirically been considered as an efficient therapeutic option to blunt sympathetic tone and control ES. Purpose The aim of this multicenter study was to determine the efficacy of deep sedation in patients presenting intractable ES refractory to anti-arrhythmic drugs. Methods Patients requiring deep sedation for refractory ES from January 1st 2007 to July 31st 2018 were retrospectively included in 13 centers. The primary endpoint was the rate of acute response to sedation, defined as ES termination within 15 minutes after deep sedation. Results Among the 116 patients, 55 (47.4%) had ES termination within 15 minutes and were considered “acute responders” to deep sedation. Clinical signs of congestive heart failure before deep sedation (OR=3.31, 95% CI:1.001–10.97, p=0.049) was the only independent predictor of non-acute response. Twenty-one non-acute responders (34.4%) had an extracorporeal membrane oxygenation (ECMO) implanted. Non-acute responders had a significantly lower in-hospital survival (Log-rank, p=0.010). ECMO implantation did not influence survival in non-acute responders to sedation. Acute response to deep sedation was an independent protector of in-hospital mortality, decreasing by 73% the risk of death (OR 0.27; 95% CI:0.10–0.70, p=0.008). Conclusion To the best of our knowledge, this multicenter study is the first analysis of the efficacy of deep sedation in patients with intractable ES refractory to anti-arrhythmic drugs, and demonstrating the positive impact of “acute response” on in-hospital survival. Funding Acknowledgement Type of funding source: None
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0c408984c71ddbe6b13221039e20bdbc https://doi.org/10.1093/ehjci/ehaa946.0752 Zobrazit plný text záznamu