BAFF-R, a Newly Identified TNF Receptor That Specifically Interacts with BAFF
Autor: | Christopher D. Benjamin, Sarah A. Bixler, Kalpit Vora, Jürg Tschopp, Jeffrey Thompson, Christine Ambrose, Catherine Hession, Martin L. Scott, Jeffrey L. Browning, Irene Sizing, Kathy Strauch, Mohammad Zafari, Pascal Schneider, Fang Qian, Teresa G. Cachero, Colleen Mullen |
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Rok vydání: | 2001 |
Předmět: |
Multidisciplinary
Chemistry Transmembrane activator and CAML interactor B-Cell Maturation Antigen Cell biology stomatognathic diseases medicine.anatomical_structure stomatognathic system immune system diseases B cell homeostasis hemic and lymphatic diseases Immunology medicine Signal transduction skin and connective tissue diseases B-cell activating factor BAFF receptor Receptor B cell |
Zdroj: | Science. 293:2108-2111 |
ISSN: | 1095-9203 0036-8075 |
Popis: | B cell homeostasis has been shown to critically depend on BAFF, the B cell activation factor from the tumor necrosis factor (TNF) family. Although BAFF is already known to bind two receptors, BCMA and TACI, we have identified a third receptor for BAFF that we have termed BAFF-R. BAFF-R binding appears to be highly specific for BAFF, suggesting a unique role for this ligand-receptor interaction. Consistent with this, the BAFF-R locus is disrupted in A/WySnJ mice, which display a B cell phenotype qualitatively similar to that of the BAFF-deficient mice. Thus, BAFF-R appears to be the principal receptor for BAFF-mediated mature B cell survival. |
Databáze: | OpenAIRE |
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