BAFF-R, a Newly Identified TNF Receptor That Specifically Interacts with BAFF

Autor:	Christopher D. Benjamin, Sarah A. Bixler, Kalpit Vora, Jürg Tschopp, Jeffrey Thompson, Christine Ambrose, Catherine Hession, Martin L. Scott, Jeffrey L. Browning, Irene Sizing, Kathy Strauch, Mohammad Zafari, Pascal Schneider, Fang Qian, Teresa G. Cachero, Colleen Mullen
Rok vydání:	2001
Předmět:	Multidisciplinary Chemistry Transmembrane activator and CAML interactor B-Cell Maturation Antigen Cell biology stomatognathic diseases medicine.anatomical_structure stomatognathic system immune system diseases B cell homeostasis hemic and lymphatic diseases Immunology medicine Signal transduction skin and connective tissue diseases B-cell activating factor BAFF receptor Receptor B cell
Zdroj:	Science. 293:2108-2111
ISSN:	1095-9203 0036-8075
Popis:	B cell homeostasis has been shown to critically depend on BAFF, the B cell activation factor from the tumor necrosis factor (TNF) family. Although BAFF is already known to bind two receptors, BCMA and TACI, we have identified a third receptor for BAFF that we have termed BAFF-R. BAFF-R binding appears to be highly specific for BAFF, suggesting a unique role for this ligand-receptor interaction. Consistent with this, the BAFF-R locus is disrupted in A/WySnJ mice, which display a B cell phenotype qualitatively similar to that of the BAFF-deficient mice. Thus, BAFF-R appears to be the principal receptor for BAFF-mediated mature B cell survival.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0c3f49fedd3f751eedb5fd6d3b5f79ec https://doi.org/10.1126/science.1061965 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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