Gut oxidative responses by chronic exposure to pollutants enhance IgE production via PGE2-dependent mechanism
| Autor: | Eunsoo Kim, Astrid Bonnegarde-Bernard, Stephen O. Opiyo, Brain M. Ahmer, Estelle Comet-Boyaka, Prosper N Boyaka |
|---|---|
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | The Journal of Immunology. 202:55.4-55.4 |
| ISSN: | 1550-6606 0022-1767 |
| Popis: | Environmental pollutants are believed to contribute to the increased incidence of allergic diseases. However, mechanisms linking exposure to pollutants with allergy are poorly understood and researches about heavy metals are mostly focused on its toxicity. Groups of mice were chronically exposed to subtoxic doses of cadmium in the drinking water. We then analyzed the impact of this exposure on gut immune homeostasis, microbiota, allergic sensitization to ingested allergen and subsequent allergic responses after allergen challenge. Chronic ingestion of subtoxic doses of cadmium increased IgE responses of mice to ingested allergen and the severity of allergy symptoms upon subsequent allergen challenge. We also found that exposure to subtoxic doses of cadmium induces dysbiosis of the gut microbiota and luminal accumulation of oxidized vitamin D3 metabolites. More importantly, we found that this microenvironment selectively enhances the activation of BAFF and the production of IgE via PGE2-dependent mechanism by intestinal epithelial cells. These findings reveal a new mechanism for the induction of IgE responses via alteration of vitamin D3 metabolism by environmental pollutants which stimulate an oxidative and inflammatory environment in the gut. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|