An efficient synthesis of a chiral carbocyclic 2′-deoxyribonucleoside synthon by directed reduction

Autor:	Alan D. Borthwick, G. G. Weingarten, Andrew James Crame, Anne M. Exall
Rok vydání:	1994
Předmět:	Reduction (complexity) Deoxyribonucleoside chemistry.chemical_compound Chemistry Stereochemistry Yield (chemistry) Organic Chemistry Drug Discovery Synthon Diol Biochemistry Combinatorial chemistry
Zdroj:	Tetrahedron Letters. 35:7677-7680
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(00)78373-0
Popis:	Directed reduction of the 1,4 hydroxy-ketone 9 and the 1,4 aldehydo-ketone 12 with NaBH(OAc)3 gave stereoselectively in high yield the 1,4 diol 10, a key intermediate required in our synthesis of chiral carbocyclic 2′-deoxyribonucleosides.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0c3da7c79285c9421fac5a3df1bd9d51 https://doi.org/10.1016/s0040-4039(00)78373-0 Zobrazit plný text záznamu