Rates of longitudinal change in 18 F‐flortaucipir PET vary by brain region, cognitive impairment, and age in atypical Alzheimer's disease
| Autor: | Philip A. Cook, David J. Irwin, Ilya M. Nasrallah, Corey T. McMillan, Jacob Dubroff, Fulvio Da Re, James C. Gee, Christopher Olm, Murray Grossman, Frederick J. Nitchie, Jeffrey S. Phillips |
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| Rok vydání: | 2021 |
| Předmět: |
Oncology
medicine.medical_specialty Epidemiology Amyloid beta Disease Cellular and Molecular Neuroscience Developmental Neuroscience Neuroimaging Internal medicine mental disorders medicine Radioligand Cognitive impairment medicine.diagnostic_test biology business.industry Health Policy Neurodegeneration Posterior cortical atrophy medicine.disease Psychiatry and Mental health Positron emission tomography biology.protein Neurology (clinical) Geriatrics and Gerontology business |
| Zdroj: | Alzheimer's & Dementia. 18:1235-1247 |
| ISSN: | 1552-5279 1552-5260 |
| Popis: | Introduction Longitudinal positron emission tomography (PET) studies of tau accumulation in Alzheimer's disease (AD) have noted reduced increases or frank decreases in tau signal. We investigated how such reductions related to analytical confounds and disease progression markers in atypical AD. Methods We assessed regional and interindividual variation in longitudinal change on 18 F-flortaucipir PET imaging in 24 amyloid beta (Aβ)+ patients with atypical, early-onset amnestic or non-amnestic AD plus 62 Aβ- and 132 Aβ+ Alzheimer's Disease Neuroimaging Initiative (ADNI) participants. Results In atypical AD, 18 F-flortaucipir uptake slowed or declined over time in areas with high baseline signal and older, more impaired individuals. ADNI participants had reduced longitudinal change in early Braak stage regions relative to late-stage areas. Discussion Results suggested radioligand uptake plateaus or declines in advanced neurodegeneration. Further research should investigate whether results generalize to other radioligands and whether they relate to changes of the radioligand binding site structure or accessibility. |
| Databáze: | OpenAIRE |
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