Prediction and experimental determination of the binary and ternary phase diagrams of (±)medetomidine hydrochloride

Autor:	Mohammad Hassan Peyrovi, Hossein Fakhraian, Ebrahim Choobdari
Rok vydání:	2013
Předmět:	Activity coefficient Thermogravimetric analysis UNIQUAC Chemistry Organic Chemistry Thermodynamics Medetomidine Catalysis Inorganic Chemistry medicine Organic chemistry Physical and Theoretical Chemistry Enantiomer Solubility Eutectic system medicine.drug Phase diagram
Zdroj:	Tetrahedron: Asymmetry. 24:801-806
ISSN:	0957-4166
DOI:	10.1016/j.tetasy.2013.05.019
Popis:	The binary phase diagram of medetomidine hydrochloride was determined based on thermogravimetric differential thermal (TGA/DTA) measurements. The binary phase diagram presented a eutectic point in the 19:81 [( R )/( S )] composition and the ternary phase diagram in the presence of 2-propanol showed a eutectic point in the 75:25 [( S )/( R )] composition, both characterizing the product as a racemic compound forming system. The solubility of enantiomeric mixtures in 2-propanol was measured at 10, 20 and 30 °C. The ideal solubility curves of the mixtures were calculated and the activity coefficients derived. A semi-empirical thermodynamic model UNIversal QUAsi-Chemical (UNIQUAC) was used to predict the solubility of various compositions of enantiomers at different temperatures. There was good agreement between the experimental solubility data of medetomidine hydrochloride and the results obtained from the UNIQUAC equation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0c2473ab0a27277b7af1d93df1c0cb9d https://doi.org/10.1016/j.tetasy.2013.05.019 Zobrazit plný text záznamu Full Text from ScienceDirect