Thio-analogues of 6-Substituted 1, 3-Dimethyl-7-azalumazine (Fervenulin) and 7-Substituted 1, 3-Dimethyl-6-azalumazine (Isofervenulin)

Autor:	Fumio Yoneda, Sadao Nishigaki, Yoshiharu Sakuma, Michiko Ueno
Rok vydání:	1973
Předmět:	Sodium dithionite chemistry.chemical_compound Fervenulin Chemistry Formic acid Drug Discovery Thio General Chemistry General Medicine Combinatorial chemistry Medicinal chemistry
Zdroj:	Chemical and Pharmaceutical Bulletin. 21:926-930
ISSN:	1347-5223 0009-2363
DOI:	10.1248/cpb.21.926
Popis:	1, 3-Dimethyl-4-thio-7-azalumazine derivatives (5-thiofervenulins) and 1, 3-dimethyl-4-thio-6-azalumazine derivatives (5-thioisofervenulins) were synthesized by the thiation of 1, 3-dimethyl-7-azalumazine derivatives (fervenulins) and 1, 3-dimethyl-6-azalumazine derivatives (isofervenulins). The 1, 3-dimethyl-4-thio-6-azalumazines were converted into theophyllines by treatment with sodium dithionite in formic acid. These thio-azalumazines displayed low antibacterial activities in vitro.
Databáze:	OpenAIRE
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