Phenolic Constituents with Antioxidant and Antiviral Activities from Phyllanthus urinaria Linnea
| Autor: | T. Q. Xu, Q. P. Liang, C. S. Wei, G. D. Tong, G. X. Zhou, C. Wu, X. Y. Jiang |
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| Rok vydání: | 2019 |
| Předmět: |
HBsAg
Antioxidant Ethanol Oxygen radical absorbance capacity biology Traditional medicine medicine.medical_treatment biology.organism_classification 030226 pharmacology & pharmacy 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine HBeAg chemistry medicine Ic50 values Phenols Phyllanthus urinaria |
| Zdroj: | Indian Journal of Pharmaceutical Sciences. 81 |
| DOI: | 10.36468/pharmaceutical-sciences.526 |
| Popis: | Phyllanthus urinaria Linnea is commonly used in folk medicine with considerable therapeutic utility. Sixteen phenols of Phyllanthus urinaria were isolated from ethanol extract and their structures were identified by spectroscopic data. Oxygen radical absorbance capacity, radical scavenging assay and HBsAg and HBeAg ELISA kits were used to evaluate antioxidant and antiviral activities. All the isolates showed significant antioxidant activity. Especially, isolates 4 and 5 had the oxygen radical absorbance capacity of 5.12 and 8.13 U/mol and strong radical scavenging activity with IC50 values of 5.50 and 5.55 μM, respectively. Additionally, these studies also demonstrated that the compounds 1, 2, 11, 12, and 16 inhibited secretion of HBsAg and HBeAg in HepG2.2.15 cells. This study suggested that the phenolic constituents of Phyllanthus urinaria possessed antioxidant activities and these might play an important role in antihepatitic effects. |
| Databáze: | OpenAIRE |
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