Nontoxic and renewable metal–organic framework based on α-cyclodextrin with efficient drug delivery
| Autor: | Xiao-Hua Zhong, Ning Sheng, Lian-He Wu, Jingquan Sha, Guo-Dong Liu |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
chemistry.chemical_classification
Cyclodextrin 010405 organic chemistry Stereochemistry Chemistry General Chemical Engineering Solvothermal synthesis General Chemistry 010402 general chemistry Biocompatible material 01 natural sciences Environmentally friendly Combinatorial chemistry 0104 chemical sciences Drug delivery Metal-organic framework Drug carrier |
| Zdroj: | RSC Advances. 6:82977-82983 |
| ISSN: | 2046-2069 |
| DOI: | 10.1039/c6ra16549d |
| Popis: | A novel α-cyclodextrin based metal–organic framework (CD-MOF) with chiral helices, K3(C36H60O30)2·7H2O (1), was synthesized by vapor diffusion method, which contains infinitely long left-handed helical chains, interdigitated with six circumambient helical chains. Compound 1 exhibits efficient drug loading capacity and excellent sustained release behavior. In addition, by changing the synthetic method, another compound based on α-cyclodextrin, (C36H60O30)·H2O (2), was isolated by solvothermal synthesis, which contains left-handed chiral helical double channels, linked with adjacent four same helical channels. Moreover, the lower cytotoxicity of the two compounds indicates that they are a type of renewable, environmentally friendly and biocompatible drug carrier material. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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