ChemInform Abstract: Chiral Phosphoric Acid Catalyzed Highly Enantioselective Desymmetrization of 2-Substituted and 2,2-Disubstituted 1,3-Diols via Oxidative Cleavage of Benzylidene Acetals
| Autor: | Kendall N. Houk, Wen-Hua Zheng, Xing-Bang Lin, Kou-Sen Cao, Shan-Shui Meng, Lufeng Zou, Yong Liang, Hui Yang |
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| Rok vydání: | 2015 |
| Předmět: |
inorganic chemicals
integumentary system organic chemicals Acetal Enantioselective synthesis General Medicine Medicinal chemistry Desymmetrization Catalysis chemistry.chemical_compound chemistry Organocatalysis polycyclic compounds heterocyclic compounds Dimethyldioxirane Oxidative cleavage Phosphoric acid |
| Zdroj: | ChemInform. 46 |
| ISSN: | 0931-7597 |
| DOI: | 10.1002/chin.201512029 |
| Popis: | This highly enantioselective reaction proceeds through formation of an “ortho ester” intermediate via oxidation of the 1,3-diol benzylidene acetal by dimethyldioxirane and a subsequent proton transfer catalyzed by chiral phosphoric acids (CPA). |
| Databáze: | OpenAIRE |
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