Recurrent major depression and right hippocampal volume: A bivariate linkage and association study
| Autor: | Ravi Duggirala, Marcio Almeida, Thomas D. Dyer, Joanne E. Curran, Peter T. Fox, Harald H H Göring, David C. Glahn, D. Reese McKay, Emma Knowles, Jack W. Kent, Samuel R. Mathias, Laura Almasy, Rene L. Olvera, John Blangero |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Radiological and Ultrasound Technology Pedigree chart Genome-wide association study Bivariate analysis Quantitative trait locus medicine.disease 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Neurology Genetic linkage Endophenotype Internal medicine medicine Major depressive disorder Radiology Nuclear Medicine and imaging Neurology (clinical) Anatomy Psychiatry Psychology 030217 neurology & neurosurgery Genetic association |
| Zdroj: | Human Brain Mapping. 37:191-202 |
| ISSN: | 1065-9471 |
| DOI: | 10.1002/hbm.23025 |
| Popis: | Previous work has shown that the hippocampus is smaller in the brains of individuals suffering from major depressive disorder (MDD) than those of healthy controls. Moreover, right hippocampal volume specifically has been found to predict the probability of subsequent depressive episodes. This study explored the utility of right hippocampal volume as an endophenotype of recurrent MDD (rMDD). We observed a significant genetic correlation between the two traits in a large sample of Mexican American individuals from extended pedigrees (ρg = -0.34, p = 0.013). A bivariate linkage scan revealed a significant pleiotropic quantitative trait locus on chromosome 18p11.31-32 (LOD = 3.61). Bivariate association analysis conducted under the linkage peak revealed a variant (rs574972) within an intron of the gene SMCHD1 meeting the corrected significance level (χ(2) = 19.0, p = 7.4 × 10(-5)). Univariate association analyses of each phenotype separately revealed that the same variant was significant for right hippocampal volume alone, and also revealed a suggestively significant variant (rs12455524) within the gene DLGAP1 for rMDD alone. The results implicate right-hemisphere hippocampal volume as a possible endophenotype of rMDD, and in so doing highlight a potential gene of interest for rMDD risk. |
| Databáze: | OpenAIRE |
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