AB0371 CLINICAL SIGNIFICANCE OF GALECTIN-3 IN PATIENTS WITH RHEUMATOID ARTHRITIS BEFORE THE APPOINTMENT AND AFTER 12 MONTHS OF TREATMENT WITH BIOLOGICAL DRUGS (PRELIMINARY DATA)

Autor: Y. Gorbunova, T. Popkova, I. Kirillova, T. Panafidina, M. Diatroptov, E. Nasonov
Rok vydání: 2022
Předmět:
Zdroj: Annals of the Rheumatic Diseases. 81:1312.2-1313
ISSN: 1468-2060
0003-4967
DOI: 10.1136/annrheumdis-2022-eular.4669
Popis: BackgroundThe role of galectin-3, a pro-inflammatory mediator involved in autoimmune disorders in patients with rheumatoid arthritis (RA), is discussed in the literature.ObjectivesTo clarify the relationship of clinical and laboratory manifestations of RA with galectin-3 with the ineffectiveness of basic anti-inflammatory therapy and after 12 months of treatment with biological drugs.MethodsThe study included 47pts (39 women /8 men) with RA, 51 [39,0; 63,0] years old. Pts were seropositive for IgM RF (79%) and anti-CCP (62%), with highly active RA (DAS28 5,7 [5,2; 6,4]; SDAI 35,0 [29,1; 43,6], CDAI 34,0 [25,0; 43,0]) scores, and median disease duration of 4.0 [3,0;14.0] years. All patients with RA had a history of insufficient effect or intolerance to two or more basic anti-inflammatory drugs (DMARDs). At the time of inclusion in the study, patients received DMARDs: 44% of patients received methotrexate (median dose - 15 (15; 20) mg /week), 35% - leflunomide (20 mg/day), 9.3 % - sulfasalazine (2000 mg/day), 7% - hydroxychloroquine (200 mg/day), 67.4% - glucocorticoids (5 (4;8) mg /day). Patients did not receive biological therapy at the time of inclusion in the study. Due to lack of efficacy or intolerance, patients with RA (n=21) were prescribed biological therapy: 52.4% - anti-B-cell therapy, 38% - TNF-alpha inhibitors, 9.6% - IL-6 inhibitors. The control group consisted of 20 age-matched donors without rheumatic diseases. Galectin 3 concentration was determined by ELISA (Bender MedSystems GmbH, Biocenter, Vienna Austria). The upper limit of normal when testing 20 sera from healthy donors was 5.32 ng/ml, corresponding to the 95th percentile.ResultsThe serum level of galectin-3 in RA patients (n=47) and in the control group (n=20) did not differ statistically significantly (4.27 [2.3;5.26] ng/ml vs 3.83 [2.57;4.11] ng/ml (p=0.1). In the whole group of RA patients (n=47) with inefficiency (insufficient effect) of basic anti-inflammatory therapy, correlations were noted between the level of galectin-3 and age (R=0.34; p=0.02), BMI (R=0.36; p=0.02), SDAI (R=0.33; p=0.02), CDAI (R=0.31; p=0.03). RA patients were divided into 2 groups: group I (n=27) - patients with galectin-3 ≥ 5.32 ng/ml; II (n= 20) - less than Table 1.Patients with RA (n=21) with insufficient effect of basic anti-inflammatory therapyPatients with RA (n=21) after 12 months of receiving combination therapyΔ,%рDAS285,6 (5,3; 6,7)3,97(3,36;4,63)*-30,40,0001SDAI38,17 (29,5; 45,8)17,2(9,57;25,6) *-54,80,0001CDAI35,0 (26,0; 43,5)17,0(9,0;23,5) *-51,40,0001СRP,mg/l20,6 (11,7;34,1)3,15(1,2;7,2) *-84,70,003ESR,mm/h27,0 (16,0;45,0)16,0 (10,0;23,5) *-40,70,003IgM RF, МЕ/ml84,4 (20,8;163,0)32,2(10,6;107) *-61,80,01Galectin-3, ng/ml4,2 [2,8;5,1]3,42 (2,56; 4,36)-190,2* -p ConclusionThere were no differences in the level of serum galectin-3 in patients with RA and with the ineffectiveness of basic anti-inflammatory therapy and in the control group. At the same time, the association of this marker with RA activity (according to the SDAI, CDAI indices) does not exclude its role in the development of clinical manifestations of rheumatoid arthritis.Disclosure of InterestsNone declared
Databáze: OpenAIRE
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