Kinetically-inert polypyridylruthenium(II) complexes as therapeutic agents

Autor:	J. Grant Collins, Anil K. Gorle, Madhu K. Sundaraneedi, Xin Li, F. Richard Keene
Rok vydání:	2018
Předmět:	Inorganic Chemistry chemistry 010405 organic chemistry Materials Chemistry chemistry.chemical_element Biological activity Physical and Theoretical Chemistry 010402 general chemistry 01 natural sciences Clinical success Combinatorial chemistry 0104 chemical sciences Ruthenium
Zdroj:	Coordination Chemistry Reviews. 375:134-147
ISSN:	0010-8545
Popis:	Due to the clinical success and limitations of platinum-based anticancer drugs, there has been considerable interest in the development of new therapeutic agents based upon other transition metals, in particular ruthenium. There have now been many studies demonstrating the anticancer and antimicrobial properties of kinetically-inert polypyridylruthenium(II) complexes. This review showcases the diverse range of polypyridylruthenium complexes that exhibit significant biological activity, and discusses the relationship between their chemical structure and biological processing (cellular uptake and localisation) in eukaryotic cells. Perhaps more importantly, this review also highlights several recent studies that have shown kinetically-inert polypyridylruthenium(II) complexes can exhibit anticancer activity in in vivo trials – studies that provide the “proof of concept” that this class of metal-based agent has real clinical potential.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0bf1733cc67e9724a43ace0e6ae0fcdd https://doi.org/10.1016/j.ccr.2017.11.011 Zobrazit plný text záznamu Full Text from ScienceDirect