Effects of Zoniporide and BMA-1321 Compound on the Rate of Oxygen Absorption by Cardiomyocyte Mitochondria in Rats with Experimental Chronic Heart Failure
| Autor: | Alexander A. Spasov, T. A. Popova, V V Vishnevskaya, V. N. Perfilova, Alexander Ozerov, M. V. Kustova, N V Ovsyankina, N. A. Gurova |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Chemistry General Medicine Pharmacology Mitochondrion medicine.disease General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Heart failure Oxygen absorption Respiration medicine Myocardial Mitochondria Respiratory control Respiratory chain complex II ZONIPORIDE 030217 neurology & neurosurgery |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 170:316-320 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-021-05059-w |
| Popis: | Uncoupling of respiration and ATP production by myocardial mitochondria was observed in rats with chronic isoproterenol intoxication (L-isoproterenol subcutaneously, 1 mg/kg, for 10 days) in comparison with controls (injected with the solvent). Inhibitors of NHE-1 zoniporide (1 mg/kg intraperitoneally, 13 days) and BMA-1321 compound (0.92 mg/kg intraperitoneally, 13 days) improved the mitochondrial function in rats with isoproterenol-induced cardiac failure: respiratory control coefficients increased, more so for the respiratory chain complex II, the main source of ROS in heart failure. The effect of BMA-1321 was more manifest (53%; p |
| Databáze: | OpenAIRE |
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