| Popis: |
Introduction: Achromobacter is a Gram-negative, motile, obligate aerobic, and non-fermentative bacterium. It is an emerging pathogen in the hospital environment as it is frequently found in various solutions. Hypothesis/Gap Statement: Information about the incidence and risk factors of Achromobacter bacteremia from India is limited. Aim: We conducted this study to identify the risk factors and underlying conditions predisposing to bacteremia by Achromobacter spp and analyze the antibiotic resistance pattern of the isolates. Methodology: We performed a retrospective observational study where automated blood cultures positive for Achromobacter spp were assessed for clinical characteristics and antibiotic susceptibility patterns from January 2022 to December 2022 in the microbiology laboratory of a tertiary care center in Northern India. Results: A total of fourteen cases of Achromobacter spp were identified from bloodstream infections in one year. The mean age of the patients was 37.59 ± 23.17 years with a male predominance (8/14, 57.1%). All patients were managed on intravenous antibiotics and intravenous access as peripheral line catheters and only 5 (5/14, 35.7%) patients were managed on central line catheters. The most common antibiotic found to be susceptible against Achromobacter spp was Ticarcillin- clavulanic acid (14/14, 100.0%) followed by Fluoroquinolones (12/14, 85.72%) and Trimethoprim- sulphamethoxazole (12/14, 85.72%). The all-cause 40-day mortality was observed in 35.7% (5/14, 35.7%) with two death that was directly attributable to sepsis. Conclusion: This study provides insight into the incidence of Achromobacter bacteremia at our center and the necessary antibiotic therapy to combat it. |
