Typing of human papillomavirus in Zimbabwean patients with invasive cancer of the uterine cervix
| Autor: | Patti Kay, S. A. Tswana, Anna-Lise Williamson, Mike Chirara, Staffan Bergström, Grazyna A. Stanczuk, Bruce Allan, Elopy Sibanda |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Cervical cancer
Gynecology medicine.medical_specialty Invasive carcinoma business.industry virus diseases Obstetrics and Gynecology General Medicine medicine.disease female genital diseases and pregnancy complications medicine.anatomical_structure Medicine Adenocarcinoma Typing Human papillomavirus Restriction fragment length polymorphism business Nested polymerase chain reaction Cervix |
| Zdroj: | Acta Obstetricia et Gynecologica Scandinavica. 82:762-766 |
| ISSN: | 0001-6349 |
| DOI: | 10.1034/j.1600-0412.2003.00245.x |
| Popis: | Background. Cervical cancer affects 1 in 2000 Zimbabwean women. We investigated the type-specific distribution of human papillomavirus (HPV) infection in Zimbabwean women with invasive cervical cancer. Methods. We conducted a descriptive study on 98 women with invasive cervical cancer. The methods used were a nested polymerase chain reaction (PCR) for amplification of HPV-DNA and restriction fragment length polymorphism (RFLP) to characterize the HPV types. Results. HPV-DNA was identified in 97% of the cases. HPV types 16, 33, 18 and 31 were identified in 61%, 39%, 18% and 4% of the patients, respectively. We typed one case each of HPV types 35 and 58. Multiple HPV infections were present in 24%. All patients ( n = 3) with adenocarcinoma of the cervix were infected with the HPV. Patients infected with HPV-16 alone presented at a median age of 46 years while those infected with HPV-33 alone presented at 43 years. However, patients coinfected with both HPV-16 and HPV-33 were between 10 and 13 years older (m... |
| Databáze: | OpenAIRE |
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