Synthesis and Anticancer, Antiinflammatory,and Analgesic Activity Evaluation of Some Sulfa Drug and Acridine Derivatives

Autor:	Ram Raghubir, Nidhi Singhal, Rakesh Shukla, Sunanda G. Dastidar, Monika Johar, Sham M. Sondhi
Rok vydání:	2000
Předmět:	chemistry.chemical_compound Sulfathiazole chemistry Sulfa drug Analgesic Acridine derivatives medicine General Chemistry Methanol Combinatorial chemistry medicine.drug
Zdroj:	Monatshefte für Chemie/Chemical Monthly. 131:0511-0520
ISSN:	0026-9247
Popis:	Various sulfa drugs were condensed with 4-isothiocyanato-4-methyl-2-pentanone at pH∼3–5 by refluxing in methanol to give various substituted mercaptopyrimidines. On condensation with 9-chloro-2-substituted or -unsubstituted acridines, sulfathiazole gave the corresponding condensed products. N-Ethylaminoadenosine reacted with 9-chloroacridine to the coupled product. Condensation of sulfathiazole with 9-isothiocyanato-2,4-substituted or -unsubstituted acridines afforded the corresponding condensed compounds. The structures of all synthesized compounds were confirmed by spectroscopic methods. Anticancer, antiinflammatory, and analgesic activities of all compounds were investigated.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0bd07aa32b347ba7c41e13f221a85534 https://doi.org/10.1007/s007060050332 Zobrazit plný text záznamu Full text from SpringerLink