Effect of vitamin E on oxidative stress indicated by serum malondialdehyde and Paroxonase level in type 2 diabetes mellitus with retinopathy
| Autor: | Fatma Abd El-Kader Attia, Zeinab Helmy El-Sayed, Jihan AbdAllah Mohamed, Eman Refaat Youness, Maha AbdAl-Wahhab Rezq Hamayel |
|---|---|
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | International journal of health sciences. :964-977 |
| ISSN: | 2550-696X 2550-6978 |
| DOI: | 10.53730/ijhs.v6ns7.11484 |
| Popis: | Background: Type 2 diabetes mellitus is a progressive condition in which the body becomes resistant to the normal effects of insulin and/or gradually loses the capacity to produce enough insulin the pancreas. Objectives: This case-control study was conducted to assess the effect of vitamin E on oxidative stress indicated by malondialdehyde and paronxanase 1 level on T2DM patients with retinopathy. Patients and Methods: Two equal groups each consisted of thirty patients; the 1st group was T2DM without retinopathy (control) and the 2nd one was T2DM with retinopathy (case). Results: There was statistically significant positive correlation Oppositely, paroxanase 1 level was statistically significantly negatively correlated with hydroperoxidase. As. Also, there was statistically significant increase on paroxanase 1 level after 3-month vitamin E application as an antioxidant among the T2DM with retinopathy group. Conclusion: Serum MDA levels were associated with DR stage, suggesting that oxidative stress play a significant role in DR progression. On the other hand, MDA levels were reduced and proliferative DR patients after vitamin E intake for 3 months. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|