Association of genetic polymorphisms of estrogen and progesterone receptors and endometriosis: Meta-analysis
| Autor: | Bruna Vicente de Oliveira, Antonio Márcio Teodoro Cordeiro Silva, Priscila Prais Carneiro |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
030219 obstetrics & reproductive medicine medicine.drug_class business.industry Endometriosis medicine.disease 03 medical and health sciences 0302 clinical medicine Endocrinology Estrogen 030220 oncology & carcinogenesis Meta-analysis Internal medicine Progesterone receptor medicine Receptor business Gene Estrogen receptor alpha Estrogen receptor beta |
| Zdroj: | Journal of Endometriosis and Pelvic Pain Disorders. 11:25-36 |
| ISSN: | 2284-0273 2284-0265 |
| DOI: | 10.1177/2284026518819516 |
| Popis: | Purpose: To investigate the association between polymorphisms in the genes of estrogen receptor alpha, estrogen receptor beta, and progesterone receptor and the genesis of endometriosis. Methods: Systematic review and meta-analysis of articles published fully in the PubMed database, in Portuguese, English, or Spanish, from 2006 to 2017, using the descriptors: “endometriosis,” “polymorphism,” “ESR1,” “ESR2,” “PROGINS,” “rs9340799,” “rs4986938,” and “rs1042838.” Results: A total of 20 studies were included based on the criterion of search for susceptibility to endometriosis related to polymorphisms of estrogen receptor alpha, estrogen receptor beta, and progesterone receptor genes. Analysis of all polymorphisms found no association with endometriosis. Conclusion: This meta-analysis showed that estrogen receptor alpha, estrogen receptor beta, and progesterone receptor polymorphisms are not related to susceptibility to endometriosis. However, such results may be able to provide more detailed interpretations of how they influence the pathogenesis of endometriosis. |
| Databáze: | OpenAIRE |
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