| Autor: |
Marianne Carlsen, Daniel L. Cheney, Junqing Guo, John S. Chorba, Robert M. Townsend, Edwin J. Iwanowicz, Henry H. Gu, Mark R. Witmer, Derek J. Norris, Katherine A. Rouleau, Zhongqi Shen, William J. Pitts, Diane Hollenbaugh, Scott H. Watterson, T. G. Murali Dhar, Catherine A. Fleener, Ping Chen |
| Rok vydání: |
2003 |
| Předmět: |
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| Zdroj: |
Bioorganic & Medicinal Chemistry Letters. 13:543-546 |
| ISSN: |
0960-894X |
| DOI: |
10.1016/s0960-894x(02)00944-7 |
| Popis: |
A series of novel quinolone-based small molecule inhibitors of inosine monophosphate dehydrogenase (IMPDH) was explored. The synthesis and the structure-activity relationships (SARs) derived from in vitro studies are described. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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Full Text from ScienceDirect 