Multiparameter study of the immunophenotype of tumor infiltrating lymphocytes, in cancer patients

Autor:	Sh. G Khakimova, Igor Samoylenko, Tat’yana N. Zabotina, A. A. Borunova, I. V. Panichenko, I. I Bokin, Kadagidze Zg, M. V Savostikova, Korotkova Ov, D.V. Tabakov, V. T. Tsiklauri
Rok vydání:	2016
Předmět:	Immunophenotyping Tumor-infiltrating lymphocytes business.industry Cancer research Medicine Cancer General Medicine business medicine.disease
Zdroj:	Russian Journal of Oncology. 21:51-54
ISSN:	2412-9119 1028-9984
Popis:	For the first time in Russia the immunophenotype of tumor infiltrated lymphocytes (TIL) was investigated with the use of a method of quantitative flow cytometry. Samples from 104 patients, suffering from solid tumors (such as breast cancer, ovarian cancer, melanoma and oral cavity squamous carcinoma), were analyzed in this investigation. In the difference of cytomorphological analysis, the method of flow cytometry identified TIL in 100% of cases. In the structure of CDS+Т- lymphocytes the ratio CD4/CD8 was equal to 1,1±0,1. Serial gating strategy allowed to assess minor subpopulations of regulatory T-lymphocytes CD45+CD4+CD127+low/neg and CD45+CD8+CD28-CD11b-. Regulatory mechanisms with involvement of CD8 T-cells played the main role in the generation of immune responses at the tissue level ofpatients, suffering from solid tumors, independent of nosological form of disease.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0ba5620c3ede39ad2e9bd8aefb7ff1fd https://doi.org/10.18821/1028-9984-2015-21-1-51-54 Zobrazit plný text záznamu