Stability Indicating HPLC Method for Determination of Racecadotril in Solid Dosage Form

Autor:	SG Vasantharaju, N. Sivagurunathan, S. Lakshmana Prabu, B. Meenashi Vanathi, C. Dinesh Kumar
Rok vydání:	2009
Předmět:	Chromatography Analytical chemistry Linearity High-performance liquid chromatography Racecadotril Dosage form Volumetric flow rate chemistry.chemical_compound chemistry Forced degradation medicine Methanol Hplc method medicine.drug
Zdroj:	Journal of Pharmaceutical Research. 8:39
ISSN:	2454-8405 0973-7200
Popis:	A simple, rapid and accurate RP-HPLC method was developed for the determination of racecadotril in solid pharmaceutical dosage form. The method showed a linear response for concentrations in the range 10-200 μg/ml using methanol: water (80:20 v/v) as the mobile phase with detection at 231 nm and a flow rate of 1.2 ml/min. Solution concentrations were measured at a weight basis to avoid the use of an internal standard. The method was statistically validated for accuracy, precision, linearity, range, ruggedness, robustness, forced degradation, solution stability, and selectivity. Quantitative and recovery studies of the dosage form were also carried out and analyzed; the % RSD from recovery studies was found to be 0.53. Due to the simplicity, rapidity and accuracy of the method, we believe that the method will be useful for routine quality control analysis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0b9ea877add82e81c906d6f4c16f106e https://doi.org/10.18579/jpcrkc/2009/8/1/79786 Zobrazit plný text záznamu