Neonatales Abstinenzsyndrom bei europäischen und nordamerikanischen Neugeborenen: Unterschiede im klinischen Verlauf an Hand von Daten einer prospektiven randomisierten Studie
| Autor: | Katrin Klebermass-Schrehof, Manfred Weninger, K. Graf-Rohrmeister, Reinhold Jagsch, L. Kirchner, Verena Metz, Anne Unger, Gabriele Fischer |
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| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Pediatrics Pregnancy business.industry Birth weight Context (language use) medicine.disease law.invention Clinical trial Randomized controlled trial law Pediatrics Perinatology and Child Health Medicine Neonatology business Prospective cohort study Buprenorphine medicine.drug |
| Zdroj: | Klinische Pädiatrie. 226:274-280 |
| ISSN: | 1439-3824 0300-8630 |
| DOI: | 10.1055/s-0034-1372586 |
| Popis: | BACKGROUND Due to the steady increase of substance-dependent pregnant women the neonatal abstinence syndrome has become an increasingly important issue in neonatology. The present study investigates site-specific differences of detailed symptoms and treatment of neonatal abstinence syndrome within the context of an international multicenter clinical trial. METHODS Site specific neonatal data analyses from a prospective randomized, double-blind, double-dummy clinical trial (MOTHER study) was performed. A standardized NAS rating and treatment protocol was applied, while non-pharmacological care of NAS symptoms differed across the sites. RESULTS Urban US neonates exhibited most neurological symptoms (p |
| Databáze: | OpenAIRE |
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