Prevalence of functional constipation and constipation-predominant irritable bowel syndrome in Indian patients with constipation
| Autor: | Ramesh Rooprai, Naresh Bhat, Mayur M. Mayabhate, Rajesh Sainani |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Constipation business.industry Peptic 05 social sciences Rome iii medicine.disease Gastroenterology 03 medical and health sciences 0302 clinical medicine Quality of life Internal medicine Concomitant Diabetes mellitus 0502 economics and business medicine Functional constipation 050211 marketing 030211 gastroenterology & hepatology medicine.symptom business Constipation predominant irritable bowel syndrome |
| Zdroj: | International Journal of Basic & Clinical Pharmacology. 6:275 |
| ISSN: | 2279-0780 2319-2003 |
| DOI: | 10.18203/2319-2003.ijbcp20170044 |
| Popis: | Background: Evaluate prevalence of functional constipation (FC) and irritable bowel syndrome-constipation (IBS-C) in Indian constipated patients and assess their demographic/socio-economic/clinical characteristics.Methods: Patients (≥18 years) who visited their general physician with symptoms of constipation (Rome III criteria for FC or IBS-C as per physician assessment) and willing to participate were enrolled in this prospective, clinical-epidemiological study. Demographic, socioeconomic status, lifestyle and dietary habits, comorbid conditions, treatment history, concomitant medications, stool form (Bristol stool form scale), severity of constipation (constipation scoring system [CSS]), constipation-related symptoms (patient assessment of constipation symptoms [PAC-SYM]) and quality of life (patient assessment of constipation-quality of life questionnaire [PAC-QoL]) were recorded.Results: Out of 925 constipated patients, 75.6% were diagnosed with FC against 24.4% with IBS-C (P < 0.0001). Patients of both subtypes had high average scores of PAC-SYM (FC: 27.1 ± 6; IBS-C: 30.1 ± 4.9) and CSS (FC: 8.4 ± 3.1; IBS-C: 11.2 ± 3), leading to high PAC-QoL score (FC: 38.1 ± 16.8; IBS-C: 42.2 ± 13.6). Hypertension (16%) and diabetes (10%) in patients with FC while acid peptic disorders (21.7%) amongst IBS-C patients were the most common comorbid conditions observed. Laxatives were the most common medication used; osmotic (32.6% versus 40.7%) and bulk laxatives (22.8% versus 37.4%) were the commonest laxatives. However, about 1/5th patients of FC were using home remedies.Conclusions: There was a higher prevalence of FC over IBS-C in Indian constipated patients; both subtypes had high frequency and severity of constipation-related symptoms and poor QoL. |
| Databáze: | OpenAIRE |
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