Magnesium Meerwein−Ponndorf−Verley−Oppenauer Reaction. The Origin of an Impurity in PDA-641 Batches

Autor:	Bogdan K. Wilk, and Jean L. Helom, Clifford W. Coughlin
Rok vydání:	1998
Předmět:	Impurity Chemistry Magnesium education Organic Chemistry Inorganic chemistry chemistry.chemical_element Physical and Theoretical Chemistry
Zdroj:	Organic Process Research & Development. 2:407-411
ISSN:	1520-586X 1083-6160
DOI:	10.1021/op980078o
Popis:	An impurity in the initial scale-up batch of PDA-641 was identified and the pathway of its formation was established. The precursor of the impurity was formed by magnesium Meerwein-Ponndorf-Verley-Oppenauer reaction during the Grignard addition step. As a result of the investigation, the level of the impurity could be reduced 6-fold in the subsequent batch.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0b8f8569debcd6823b1b3ca341f5aa48 https://doi.org/10.1021/op980078o Zobrazit plný text záznamu