Core-Shell Assembly of Natural Polymers for Adjusting Release Performance of Diclofenac

Autor: Wen-Zhuo Li, Ge-Fei Li, Jian-Lin Wang
Rok vydání: 2013
Předmět:
Zdroj: International Journal of Polymeric Materials. 62:358-361
ISSN: 1563-535X
0091-4037
DOI: 10.1080/00914037.2012.702322
Popis: A series of composite materials have been prepared through assembly of two natural polymers, attapulgite and silk fibroin, to adjust the slow release performances of diclofenac molecules, a type of non-steroidal drugs. The assembled composite materials have a core-shell structure, with attapulgite composing the core and silk fibroin composing the shell. It has been found that the formation of the core-shell structure can reduce the release rate of diclofenac to a higher extent. When a small amount of ammonium molybdate was introduced into the composite material's silk fibroin layer, different release performances of drug molecules could be produced. In particular, the release performances of drug molecules contained in the assembled composite materials could be adjusted through UV irradiation. Characterization of the assembled composite materials and mechanism researches of release behaviors of the diclofenac molecules have been conducted by PXRD, SEM, IR, elemental analysis, and zeta potential, etc., in ...
Databáze: OpenAIRE
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