Genome-wide identification of aberrant alternative splicing and RNA-binding protein regulators in acute myeloid leukaemia which may contribute to immune microenvironment remodelling

Autor: Ying Yang, Yu-Mei Zhang, Yan Wang, Kui Liu, Si-Yuan Cui, Ya-Qin Luo, Wei Zheng, Jie Xu, Wei Duan, Jing-Yi Wang
Rok vydání: 2023
Předmět:
Zdroj: Carcinogenesis.
ISSN: 1460-2180
0143-3334
DOI: 10.1093/carcin/bgad032
Popis: Acute myeloid leukaemia (AML) is one of the most lethal cancers of the haematopoietic system with a poorly understood aetiology. Recent studies have shown that aberrant alternative splicing (AS) and RNA-binding protein (RBP) regulators are highly associated with the pathogenesis of AML. This study presents an overview of the abnormal AS and differential expression of RNA-binding proteins (RBPs) in AML and further highlights their close relation to the remodelling of the immune microenvironment in AML patients. An in-depth understanding of the regulatory mechanism underlying AML will contribute to the future development of strategies for the prevention, diagnosis and therapy of AML and thus improve the overall survival of patients with AML.
Databáze: OpenAIRE