ARID1A protein expression in endometriosis-associated ovarian carcinomas

Autor:	Wresnindyatsih, Aida Farida, Zen Hafy, Venni Yuliantini
Rok vydání:	2019
Předmět:	History medicine.medical_specialty ARID1A business.industry Endometriosis medicine.disease Gastroenterology Computer Science Applications Education Serous fluid Germline mutation Internal medicine Ovarian carcinoma Clear cell carcinoma medicine Stage (cooking) business Cause of death
Zdroj:	Journal of Physics: Conference Series. 1246:012070
ISSN:	1742-6596 1742-6588
DOI:	10.1088/1742-6596/1246/1/012070
Popis:	Epithelial ovarian carcinoma is leading cause of death among gynaecologic malignancies. Somatic mutation of ARID1A gene often observed in endometriosis-associated ovarian carcinoma cases. This mutation causes loss of ARID1A protein expression on tumor-bearing tissues. This study aims to investigate ARID1A protein expression in endometriosis-associated ovarian carcinoma cases in Indonesia. The archive of Formalin-fixed paraffin embedded (FFPE) tissue of 11 endometrial carcinomas (EC), 16 clear cell carcinoma (CCC), and 23 serous carcinomas (SC) from January 1, 2016, to December 31, 2017. The ARID1A expression were analyzed by using Kolmogorov Smirnov and Fisher’s Exact Tests. Majority of patients were older than 50 years (90%). Loss of ARID1A expression in tumor tissue was significantly low in the SC group (8.7%) compared to the EC group (27.3%) and the CCC group (62.5%) (p = 0.021). This study showed that ARID1A expression, was not associated with FIGO stage (p = 0,423), and with histological grade of the cases in EC group (p = 0,544) and SC group (p = 0,395). Loss of ARID1A expression was more frequently found in EC and CCC cases. Loss of ARID1A expression was not associated with FIGO stage and histological grade.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0b79dd4ed7a85f328c498c0c8c5c4422 https://doi.org/10.1088/1742-6596/1246/1/012070 Zobrazit plný text záznamu