Tissue-Specific Expression of Genes Involved in Cellular Transportation in Common Carp (Cyprinus carpio) Exposed to Cadmium
| Autor: | D. D. Zhdanov, Nikolay V Bodoev, Konstantin V. Zolotarev, Marina V. Mikhailova, Valeriya I. Nakhod, Kirill V. Nakhod, Anton N. Mikhailov |
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| Rok vydání: | 2021 |
| Předmět: |
Gill
Cadmium biology Voltage-dependent calcium channel Health Toxicology and Mutagenesis chemistry.chemical_element 04 agricultural and veterinary sciences General Medicine 010501 environmental sciences Toxicology biology.organism_classification 01 natural sciences Pollution Molecular biology Cyprinus Common carp chemistry Downregulation and upregulation 040103 agronomy & agriculture Cyprinidae 0401 agriculture forestry and fisheries Gene 0105 earth and related environmental sciences |
| Zdroj: | Bulletin of Environmental Contamination and Toxicology. 106:978-982 |
| ISSN: | 1432-0800 0007-4861 |
| Popis: | Juvenile common carp were treated with Cd2+ at a sublethal concentration for Cyprinidae (6.4 mg/L). The expression of N-methyl-D-aspartate receptor subunit genes (NR2A, NR2B) and ATP-binding cassette subfamily C member 1 gene (ABCC1) was compared between treated and untreated fish. In addition, cadmium accumulation in the fish tissues was assessed. NR2A was 18.9-fold upregulated by Cd2+ in the eyes (choroid + retina), which accumulated Cd, and was not upregulated in brain, which didn’t accumulate Cd. This may have been caused by the blocking of calcium channels by Cd2+, which has a very similar ionic radius to that of Ca2+. ABCC1 was 2.6-fold upregulated in gills and was not upregulated in liver; both tissues accumulated high levels of Cd. This difference may have been caused by the accumulation of predominantly previously inactivated Cd in liver or by some difference in the mechanisms of self-detoxification from Cd2+ in fish gills and liver. |
| Databáze: | OpenAIRE |
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