A New β-Carboline Alkaloid From the Aerial Part of Hedyotis capitellata

Autor:	Hoang Son Vu, Nguyen Thi Thu Hau, Bui Huu Tai, Le Thi Huyen, Nguyen Thi Lan Huyen, Phan Van Kiem, Nguyen Xuan Nhiem
Rok vydání:	2021
Předmět:	Pharmacology chemistry.chemical_compound β carboline alkaloid Complementary and alternative medicine chemistry Stereochemistry Alkaloid Drug Discovery Anthraquinones Plant Science General Medicine Anthraquinone Hedyotis capitellata
Zdroj:	Natural Product Communications. 16:1934578X2110477
ISSN:	1555-9475 1934-578X
Popis:	A new β-carboline alkaloid, 10-hydroxy-capitelline (1) together with three known anthraquinones, hedanthroside B (2), hedanthroside C (3), and rubiadin (4) were isolated from the aerial part methanol extract of Hedyotis capitellata. Their structures were established by spectroscopic data (one-dimensional, two-dimensional nuclear magnetic resonance (1D, 2D-NMR) and high-resolution-electrospray ionization-mass spectrometry, HR-ESI-MS) and comparison with those reported in the literature. The anti-inflammatory activity of the isolated compounds is evaluated by their inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. At a concentration of 20 µM, compounds 1 to 4 showed weak inhibitory effects on NO production with inhibitory values ranging from 1.2% to 23.9% compared to a value of 74.5% for the positive control compound, NG-monomethyl-L-arginine (L-NMMA).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0b736ace87b0800aa23080ce269b4abc https://doi.org/10.1177/1934578x211047705 Zobrazit plný text záznamu