Role of Sirtuins in Regulating Pathophysiology of the Heart

Autor:	Vinodkumar B. Pillai, Mahesh P. Gupta, Samik Bindu
Rok vydání:	2016
Předmět:	0301 basic medicine biology Sirtuin 1 Extramural Endocrinology Diabetes and Metabolism Cell biology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Endocrinology 030220 oncology & carcinogenesis Sirtuin biology.protein Neuroscience
Zdroj:	Trends in Endocrinology & Metabolism. 27:563-573
ISSN:	1043-2760
DOI:	10.1016/j.tem.2016.04.015
Popis:	Cardiovascular diseases (CVDs) are expanding at an alarming rate and people's propensity to develop them increases with age. Growing evidence indicates that sirtuins play a pivotal role in regulating a multitude of age-related diseases. Sirtuins are versatile molecules conserved from archaea to mammals. They are regulated by various metabolic and environmental stimuli. Seven sirtuin homologs (SIRT1-7) are present in mammals, with diverse cellular locations. Recent studies have delineated roles of sirtuins in regulating cardiac pathophysiological conditions under various stressors. SIRT1 is the most extensively studied sirtuin, while the role of other sirtuins in maintaining cardiac growth and function is still emerging. In this review we discuss the present understanding of the role of sirtuins in regulating pathophysiological conditions of the heart.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0b6b1a371c1cfb9b1206cc244b4ddd29 https://doi.org/10.1016/j.tem.2016.04.015 Zobrazit plný text záznamu Full Text from ScienceDirect