Impact of microscopic extra-nodal extension (ENE) on locoregional recurrence following curative surgery for papillary thyroid carcinoma
| Autor: | Tony W. H. Shek, Brian Hung-Hin Lang, Koon Yat Wan |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
business.industry medicine.medical_treatment Nodal metastasis Urology 030209 endocrinology & metabolism Neck dissection General Medicine Surgery Thyroid carcinoma 03 medical and health sciences 0302 clinical medicine Oncology 030220 oncology & carcinogenesis medicine Curative surgery Thyroglobulin Extra nodal Lymph business Ene reaction |
| Zdroj: | Journal of Surgical Oncology. 113:526-531 |
| ISSN: | 0022-4790 |
| DOI: | 10.1002/jso.24180 |
| Popis: | Background The presence of microscopic extra-nodal extension (ENE) may increase locoregional recurrence (LRR) in papillary thyroid carcinoma (PTC). We aimed to evaluate the association between microscopic ENE, response to initial therapy and LRR risk following total thyroidectomy, therapeutic neck dissection, and radioactive iodine (RAI) ablation in PTC. Methods Of the 369 eligible PTC patients, 264 (71.5%) did not have microscopic ENE (group I) while 105 (28.5%) did (group II). All presented with clinical nodal metastasis (cN1) and underwent therapeutic neck dissection and RAI ablation. Biochemical incompleteness meant post-ablation stimulated thyroglobulin (sTg) >10 ng/ml. Multivariate analyses were conducted to identify independent factors for LRR. Results Biochemical incompleteness was significantly more common group II (43.8% vs. 17.4%, P |
| Databáze: | OpenAIRE |
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