Cytotoxic triterpenoids from Schima crenata
| Autor: | Bai Lian Liu, Zhong Qiu Liu, Guang Xiong Zhou, Shu Qing Xiang, Peng Wu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Cisplatin
Traditional medicine Chemistry Plant Science Biochemistry Triterpenoid visual_art Ic50 values visual_art.visual_art_medium medicine Cytotoxic T cell Bark Schima crenata Cytotoxicity Agronomy and Crop Science Two-dimensional nuclear magnetic resonance spectroscopy Biotechnology medicine.drug |
| Zdroj: | Phytochemistry Letters. 45:44-47 |
| ISSN: | 1874-3900 |
| DOI: | 10.1016/j.phytol.2021.07.008 |
| Popis: | Four new triterpenoids (1-4), along with five known triterpenoids (5-9), were isolated from the bark and twigs of Schima crenata. Their structures were elucidated by the use of extensive spectroscopic methods (UV, IR, HR-ESI-MS, 1D and 2D NMR). Most of the compounds were evaluated for their cytotoxicity against the A375, A549, and LoVo cancer cell lines. Compounds 4, 8, and 9 displayed inhibitory activity against three tumor cell lines with IC50 values ranging from 3.63 ± 1.86–8.64 ± 1.55 μM, even stronger than the positive control cisplatin. |
| Databáze: | OpenAIRE |
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