Synthesis of Squalamine Utilizing a Readily Accessible Spermidine Equivalent

Autor:	Meenakshi N. Rao, Xuehai Zhang, Susan Wilder, Ani Sarkahian, Stephen R. Jones, Penina Feibush, Brad Snyder, William A. Kinney, Bin Shao, Ilya Sharkansky, Larry Mallis, Joshua E. Turse, Nathan R. Tzodikov, Ronald Michalak, Hans Jørgen Kjærsgaard, Melissa A. McGuigan, Binyamin Feibush
Rok vydání:	1998
Předmět:	Spermidine chemistry.chemical_compound chemistry Squalamine Organic Chemistry Combinatorial chemistry Chemical synthesis
Zdroj:	The Journal of Organic Chemistry. 63:8599-8603
ISSN:	1520-6904 0022-3263
DOI:	10.1021/jo981344z
Popis:	have both propelled clinical development ofantiangiogenic agents such as squalamine. Although themajority of the squalamine used in preclinical studieswas obtained by extraction and purification of dogfishlivers, this source was projected to be too costly andunreliable to provide adequate supplies for clinical trials.Therefore, we directed our efforts to a cost-effectivechemical synthesis.The published syntheses of squalamine were not suit-able for this purpose. The chemical synthesis of squal-amine has been demonstrated in 17 steps from both 3
Databáze:	OpenAIRE
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