Short Communication: Protective Effects of Cyperus Rotundus Extract on Amyloid β-Peptide (1-40)-Induced Memory Impairment in Male Rats: A Behavioral Study
| Autor: | Ronak Shabani, Molavi N, Soleimani Asl S, Zahra Taslimi, Shojaee A, Hashem Dabaghian F, Mehdi Mehdizadeh |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Neurology Clinical neuroscience business.industry Pharmacology medicine.disease medicine.disease_cause Pathogenesis 03 medical and health sciences Cellular and Molecular Neuroscience 030104 developmental biology 0302 clinical medicine medicine Dementia Memory impairment Neurology (clinical) Alzheimer's disease business Neuroscience 030217 neurology & neurosurgery Oxidative stress Cyperus rotundus |
| Zdroj: | Basic and Clinical Neuroscience Journal. 8:249-254 |
| ISSN: | 2228-7442 2008-126X |
| DOI: | 10.18869/nirp.bcn.8.3.249 |
| Popis: | INTRODUCTION The Alzheimer Disease (AD) is the most common form of dementia that leads to memory impairment. As the oxidative stress plays an important role in AD pathogenesis, the current study aimed at examining the protective effects of Cyperus Rotundus as an antioxidant on amyloid β (Aβ)-induced memory impairment. METHODS Twenty-eight Wistar male rats received intrahippocampal (IHP) injection of the Aβ (1-40) and C. rotundus (400 mg/kg, intraperitoneally). Spatial memory was assessed by the Morris water-maze (MWM) task. RESULTS In the MWM, Aβ (1-40) significantly increased escape latency and traveled distance (P |
| Databáze: | OpenAIRE |
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