Classification of oral clefts by affection site and laterality: a genotype-phenotype correlation study

Autor:	Marcella Martinelli, Luca Scapoli, F. Carls, Mauro Tognon, Antonio Farina, G B Nardelli, Furio Pezzetti, Paolo Carinci, D F Wyszynski, Francesco Carinci
Rok vydání:	2002
Předmět:	medicine.medical_specialty Primary palate business.industry Dentistry Orthodontics Biology Latent class model Genotype phenotype Correlation Otorhinolaryngology Genetic linkage Bilateral cleft lip Internal medicine Laterality medicine Surgery Oral Surgery Secondary palate business
Zdroj:	Orthodontics & Craniofacial Research. 5:185-191
ISSN:	1601-6335
DOI:	10.1034/j.1600-0544.2002.02204.x
Popis:	Structured Abstract Objectives – The aim of this study was to classify the phenotypes found in a series of patients with non-syndromic cleft lip (CL) with or without cleft palate (CP) and isolated cleft palate. Additionally, the frequency distribution of cases belonging to families linked to markers on chromosomes 6 and 2 within these phenotypic patterns were estimated. Design – A retrospective examination of all the available affected cases collected in Italy. Setting and Sample Population – Ninety-seven affected subjects aged 5–18 years belonging to 38 families were considered. Patterns were identified by variance of the cleft (lip, primary palate, secondary palate) and stratified according to the side of occurrence (right, left, or bilateral). Latent class analysis was used as main statistical tool for carrying out the results. Results – Three homogenous classes were identified (P
Databáze:	OpenAIRE
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