Mass sectrometric study of methylene cross-linked derivatives of adenine and adenosine

Autor:	Robert Shapiro, Chris F. Gelijkens, James A. McCloskey, Barry A. Brandes, Satinder K. Sethi
Rok vydání:	1983
Předmět:	Stereochemistry Mass spectrometry Adenosine chemistry.chemical_compound chemistry Fragmentation (mass spectrometry) medicine Mass spectrum Methylene Spectroscopy Electron ionization Bond cleavage DNA medicine.drug
Zdroj:	Biological Mass Spectrometry. 10:665-670
ISSN:	1096-9888 0306-042X
Popis:	Mass spectra of model methylene cross-linked bases and nucleosides have been studied to provide a more complete understanding of their electron ionization mass spectra for characterization of chemically modified products isolated from RNA or DNA. Four adenine and four adenosine derivatives were prepared having (CH2)n cross links between N6 groups where n = 1−4. Principal fragmentation processes are associated with homolytic cleavage of the methylene chain, often with olefin ion formation by a process associated with the presence of both bases. The fragment ions formed provide a clear means of differentiating base-base linkages from base-sugar or sugar-sugar linkages.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0b4c81e9f579748ada553e4ea35a945d https://doi.org/10.1002/bms.1200101209 Zobrazit plný text záznamu Plný text