Stereospecific Synthesis of cis-2,5-Disubstituted Pyrrolidines via N,O-Acetals Formed by Hydroamination Cyclization–Hydroalkoxylation of Homopropargylic Sulfonamides in HFIP

Autor:	Weixing Chang, Weiguo Xiao, Xiaodan Zuo, Xiaoyu Shi, Lingyan Liu, Weilin Wang, Xiaohui Cao, Jing Li
Rok vydání:	2020
Předmět:	Stereospecificity Nucleophile 010405 organic chemistry Chemistry Organic Chemistry Stereoselectivity Hydroamination 010402 general chemistry 01 natural sciences Medicinal chemistry Hydroalkoxylation 0104 chemical sciences
Zdroj:	The Journal of Organic Chemistry. 85:7045-7059
ISSN:	1520-6904 0022-3263
DOI:	10.1021/acs.joc.0c00403
Popis:	We reported a novel two-step stereoselective synthesis of functionalized pyrrolidines from homopropargylic sulfonamides and nucleophiles via an isolable N,O-acetals intermediates. This reaction fea...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0b4c59377357ec23cdcdf9c096a4477b https://doi.org/10.1021/acs.joc.0c00403 Zobrazit plný text záznamu