A Potential Linkage Between the JC and BK Polyomaviruses and Brain and Urinary Tract Tumors: A Review of the Literature
| Autor: | Francesca Elia, Sonia Villani, Serena Delbue, Pasquale Ferrante, Lucia Signorini, Silvia Carluccio |
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| Rok vydání: | 2014 |
| Předmět: |
Microarray
biology business.industry viruses Progressive multifocal leukoencephalopathy Cell JC virus virus diseases Cancer medicine.disease_cause medicine.disease Bioinformatics biology.organism_classification Virology BK virus Polyomaviridae medicine.anatomical_structure Antigen medicine General Earth and Planetary Sciences business General Environmental Science |
| Zdroj: | Advances in Tumor Virology. 4:17-24 |
| ISSN: | 1179-5654 |
| DOI: | 10.4137/atv.s12427 |
| Popis: | JC virus (JCV) and BK virus (BKV) belong to the Polyomaviridae family and were the first human polyomaviruses (PyVs) discovered. Both JCV and BKV remain latent in the kidneys and can reactivate in immunocompromised hosts, causing progressive multifocal leukoencephalopathy (PML) and nephropathy, respectively. PyVs induce cell transformation in vitro and in animal models, where they infect non-permissive cells. The molecular mechanisms of tumor formation are based on the large tumor antigen (T Ag) protein, which is able to bind and inactivate pRb and p53, inducing uncontrolled cell cycle progression. Many studies on clinical samples also indicate a positive association between JCV and BKV and human solid tumors; however no direct involvement of PyVs in the development of human cancers has been demonstrated. In this review we focused on the potential association between JCV and BKV with brain and urinary tract tumors, respectively. |
| Databáze: | OpenAIRE |
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