Lack of Evidence for the Dichotomy of TH1 and TH2 Predominance in HIV-Infected Individuals

Autor:	James F. Demarest, Oren J. Cohen, Anthony S. Fauci, Rafick Pierre Sekaly, Jean-Pierre Fortin, Kira R. Gantt, Cecilia Graziosi, Giuseppe Pantaleo
Rok vydání:	1994
Předmět:	Multidisciplinary medicine.medical_treatment T cell Cell Disease Biology Phenotype Virology medicine.anatomical_structure Cytokine Immunology medicine Interferon gamma Lymph CD8 medicine.drug
Zdroj:	Science. 265:248-252
ISSN:	1095-9203 0036-8075
Popis:	A switch from a T helper 1 (TH1) cytokine phenotype to a TH2 phenotype has been proposed as a critical element in the progression of human immunodeficiency virus (HIV) disease. Here, constitutive cytokine expression was analyzed in unfractionated and sorted cell populations isolated from peripheral blood and lymph nodes of HIV-infected individuals at different stages of disease. Expression of interleukin-2 (IL-2) and IL-4 was barely detectable (or undetectable) regardless of the stage of disease. CD8+ cells expressed large amounts of interferon gamma and IL-10, and the levels of these cytokines remained stably high throughout the course of infection. Furthermore, similar patterns of cytokine expression were observed after stimulation in vitro of purified CD4+ T cell populations obtained from HIV-infected individuals at different stages of disease. These results indicate that a switch from the TH1 to the TH2 cytokine phenotype does not occur during the progression of HIV disease.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0b3ce6318fdeff46a45d2fd2d866a237 https://doi.org/10.1126/science.8023143 Zobrazit plný text záznamu Plný text ve formátu PDF