Synthesis and biological evaluation of new spirooxindoles with embedded pharmacophores
| Autor: | Sadasivam Mathusalini, Thangaraj Arasakumar, Ramaraj Thirugnanasampandan, Krishnasamy Lakshmi, Madhusudhanan Gogul Ramnath, Chia Her Lin, Palathurai Subramaniam Mohan |
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| Rok vydání: | 2016 |
| Předmět: |
010405 organic chemistry
Chemistry Regioselectivity General Chemistry 010402 general chemistry 01 natural sciences Catalysis Cycloaddition 0104 chemical sciences chemistry.chemical_compound Materials Chemistry Organic chemistry Methylene Pharmacophore Single crystal Two-dimensional nuclear magnetic resonance spectroscopy Biological evaluation |
| Zdroj: | New Journal of Chemistry. 40:5164-5169 |
| ISSN: | 1369-9261 1144-0546 |
| DOI: | 10.1039/c6nj00534a |
| Popis: | A regioselective synthesis of new mono and bisoxindoles containing bis spiro heterocyclic hybrids has been envisaged via 1,3-dipolar cycloaddition of azomethine ylides with the dipolarophile (E)-3-((2-methoxyquinolin-3-yl)methylene)indolin-2-one, obtained through the base catalyzed condensation of indolin-2-one with substituted 2-methoxyquinoline-3-carbaldehyde. The regiochemistry and stereochemistry of the synthesized products were characterized by 1D and 2D NMR techniques and single crystal X-ray diffraction studies. Many of the compounds were found to show in vitro antioxidant, antidiabetic and acetylcholinesterase inhibitory activities. |
| Databáze: | OpenAIRE |
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