Classical and dynamic resolution of 1-amino-3-methyl-1,3,4,5-tetrahydrobenzo[d]azepin-2-one

Autor:	Thomas M. Koenig, James E. Audia, Mcdaniel Stacey L, Lynne A. Hay, Nissen Jeffrey S, David Mitchell
Rok vydání:	2005
Předmět:	Inorganic Chemistry Chemistry Computational chemistry Organic Chemistry Resolution (electron density) Analytical chemistry Physical and Theoretical Chemistry Enantiomer Dynamic resolution Catalysis
Zdroj:	Tetrahedron: Asymmetry. 16:3814-3819
ISSN:	0957-4166
DOI:	10.1016/j.tetasy.2005.10.037
Popis:	Two efficient production processes of enantioenriched 1-amino-3-methyl-1,3,4,5-tetrahydro-benzo[d]azepin-2-one 1 were achieved using the readily available starting materials. A key step in the methodologies is a classical resolution or a dynamic resolution that provides excellent chemical (>80%) yields and enantiomeric excesses (>99.8% ee). The classical resolution was developed on a preparative scale while the dynamic resolution was implemented on a pilot plant scale.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0b276dba997f406b301b16e23ad69ec3 https://doi.org/10.1016/j.tetasy.2005.10.037 Zobrazit plný text záznamu Full Text from ScienceDirect