Macrophage-Lymphocyte Interaction and Genetic Control of Immune Responsiveness

Autor: Alan S. Rosenthal, Yokomuro K, Joyce Schroer, Blake Jt, James W. Thomas
Rok vydání: 1980
Předmět:
Zdroj: Advances in Experimental Medicine and Biology ISBN: 9781468489163
DOI: 10.1007/978-1-4684-8914-9_15
Popis: We have reviewed briefly some of the diverse functions of macrophages in the immune response. Clearly, this population of cells interact physically with lymphoid cells, are required for activation of T cells, and process various protein antigens. Finally, we have studied the immune response to insulin in order to unify these previous data in such a way to demonstrate the active role of macrophages in the regulation of the immune response. The function of the Ir gene in the guinea pigs appears to be an intramolecular selection of discrete regions within the antigen for recognition by the T cell. The data presented suggest that this function operates at the level of the macrophage.
Databáze: OpenAIRE