Eminence Grise of the Genome: Long Non-Coding Ribonucleic Acids in oral Squamous Cell Carcinomas

Autor:	Soumya Makarla, Radhika M Bavle, Reshma Venugopal, Sudhakara Muniswamappa
Rok vydání:	2020
Předmět:	Genetics stomatognathic diseases medicine.anatomical_structure Cell medicine Biology Genome Coding (social sciences)
Zdroj:	Global Journal of Medical Research. :35-46
ISSN:	2249-4618 0975-5888
DOI:	10.34257/gjmrjvol20is5pg35
Popis:	Non-coding ribonucleic acids (ncRNAs) are a class of RNA molecules that are transcribed but not translated into proteins, but they affect various cellular processes. Around 60% of genes in humans do not code proteins but regulate target gene expression. Presently, a lot of research is carried out on ncRNA involvement in oral squamous cell carcinoma (OSCC) and its precursor lesions termed as oral potentially malignant disorders (OPMDs). They are broadly classified as small ncRNAs (sncRNA) and long ncRNAs (lncRNA). sncRNAs are extensively studied, whereas the divulgence of lncRNAs in OSCCs needs more revelation, hence reviewed in the present article. LncRNAs have a base pair length of more than 200, can form complex structures and influence the gene expression in a multifaceted pattern that attracts interest.
Databáze:	OpenAIRE
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