| Autor: |
Erik A. Burlingame, Jeremy Cetnar, Yuki Chin, Melissa H. Wong, Sidharth K. Sengupta, Charles D. Lopez, Daniel Clayburgh, Charles E. Gast, Skye C. Mayo, Alison H. Skalet, Young Hwan Chang, Ariana Sattler, Kristen E. Limbach, Rodney F. Pommier, Joe W. Gray, Su Ellen J. Pommier, Zahi Mitri, Yu-Jui Chiu, Kevin G. Billingsley, John R. Swain, Michael S. Parappilly, Brett C. Sheppard, Luai Zarour, Koei Chin, Gordon B. Mills, Ajay Sapre, Seunggu J. Han, Thomas L. Sutton, V. Liana Tsikitis, Austin Gower, Jared M. Fischer, Jennifer Eng, Jose L. Montoya Mira, Brett S. Walker, Kellie J. Nazemi, Jerry J. Jaboin, Matthew S. Dietz |
| Rok vydání: |
2021 |
| Předmět: |
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| Popis: |
Metastatic progression defines the final stages of tumor evolution and underlies the majority of cancer-related deaths. The heterogeneity in disseminated tumor cell populations capable of seeding and growing in distant organ sites contributes to the development of treatment resistant disease. We recently reported the identification of a novel tumor-derived cell population, circulating hybrid cells (CHCs), harboring attributes from both macrophages and neoplastic cells, including functional characteristics important to metastatic spread. These disseminated hybrids outnumber conventionally defined circulating tumor cells (CTCs) in cancer patients. It is unknown if CHCs represent a generalized cancer mechanism for cell dissemination, or if this population is relevant to the metastatic cascade. Herein, we detect CHCs in the peripheral blood of patients with cancer in myriad disease sites encompassing epithelial and non-epithelial malignancies. Further, we demonstrate that in vivo-derived hybrid cells harbor tumor-initiating capacity in murine cancer models and that CHCs from human breast cancer patients express stem cell antigens, features consistent with the ability to seed and grow at metastatic sites. Finally, we reveal heterogeneity of CHC phenotypes reflect key tumor features, including oncogenic mutations and functional protein expression. Importantly, this novel population of disseminated neoplastic cells opens a new area in cancer biology and renewed opportunity for battling metastatic disease.Simple SummaryThere is an incomplete understanding of circulating neoplastic cell populations and the fundamental mechanisms that drive dissemination, immune evasion, and growth —all critical information to more effectively prevent and treat cancer progression. A novel disseminated tumor cell population, circulating hybrid cells, are detected across many cancer types and carry functional tumor-initiating properties. Additionally, circulating hybrid cells are found at significantly higher levels than conventionally defined circulating tumor cells. Our study demonstrates that neoplastic hybrid cells harbor phenotypic and genetic characteristics of tumor and immune cells, display stem features, and are a generalizable phenomenon in solid tumors. Circulating hybrid cells therefore have relevance as a novel biomarker and open a new field of study in malignancy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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